Cheminformatics approaches to creating new hair dyes | 10/23/2018 | Staff
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Researchers use the Max Weaver Dye Library to find new, safer hair-coloring products. Credit: George Van Den Driessche.

Finding the next generation of safer hair dyes may be as simple as going to the library – in this case, NC State's Max Weaver Dye Library. The dye library, donated by the Eastman Chemical Company, contains nearly 100,000 unique dyes waiting to be fashioned into the products of tomorrow.

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Researchers from NC State's College of Textiles and the Department of Chemistry searched the Max Weaver Dye Library for compounds with high chemical similarity to known reference hair dyes. Chemical similarity is a measurement of the number of shared structural properties between two compounds. The goal is to discover possible dyes that could be used in next-generation hair-color products that are safer for consumers, stylists and the environment.

A computer-based similarity search, a cheminformatics tool for measuring chemical similarity, was performed to examine more than 2,100 digitized library dyes. The researchers found a subset of 158 compounds with high chemical similarities to the reference hair dyes. Further study reduced viable hair dye candidates down to four dyes and then further down to the two most promising Max Weaver Dye candidates.

Subclass - Dyes - Promise - Use - Hair

"We now have potentially a new subclass of dyes that hold promise for use in hair," says Tova Williams, a former NC State Ph.D. student and lead author of a journal article about the research. "One in particular has the potential to have a...
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