New protein sequencing method could transform biological research

phys.org | 10/22/2018 | Staff
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A team of researchers at The University of Texas at Austin has demonstrated a new way to sequence proteins that is much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time. The advance could have a major impact in biomedical research, making it easier to reveal new biomarkers for the diagnosis of cancer and other diseases, as well as enhance our understanding of how healthy cells function.

The team published the results of their proof-of-concept study today in the journal Nature Biotechnology.

DNA-sequencing-like - Technology - Proteins - Edward - Marcotte

"We have created, essentially, a DNA-sequencing-like technology to study proteins," said Edward Marcotte, professor of molecular biosciences and co-inventor of the new technology.

Work on this project began more than six years ago when Marcotte and colleagues first envisioned adapting the methods of next generation gene sequencing to protein sequencing. Next generation gene sequencing is a set of techniques that have made sequencing the entire genome of any living organism fast, accurate and affordable, accelerating biological research—and for the rest of us, enabling at-home genetic testing for ancestry and disease.

Way - Advances - Information - Thousands - Genes

In the same way that these earlier advances provided quick and comprehensive information about thousands of genes that influence human health, the new technology provides for rapid and comprehensive information about tens of thousands of proteins that play a role in healthy functioning or in diseases. In many disorders—such as cancer, Alzheimer's, heart failure...
(Excerpt) Read more at: phys.org
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