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NUS pharmaceutical scientists have developed a simple, yet highly sensitive probe to detect the fat mass and obesity-associated protein (FTO) levels in cells. This can potentially help in the early detection and diagnosis of metabolic diseases such as diabetes.
Diabetes is becoming a serious health issue in Singapore. However, because it often begins with few noticeable symptoms, it is frequently left undiagnosed until it has progressed to later stages of the disease. By then, complications such as eye damage, kidney diseases and cardiovascular diseases may have developed. There is therefore a need for better screening tools to allow for more efficient and earlier diagnosis of this disease.
Prof - Esther - Woon - Department - Pharmacy
Prof Esther Woon from the Department of Pharmacy, NUS and her team have developed a fluorescent probe that can directly detect FTO activity levels in living cells. The FTO protein is strongly associated with a range of metabolic disorders such as obesity and diabetes. The detection is achieved by using a dynamic ribonucleic acid (RNA) probe which, by design, has the capacity to assume different conformations according...
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