Genetics of brain structure and description of largest human genetic study

ScienceDaily | 10/10/2018 | Staff
madalina09madalina09 (Posted by) Level 4
These genetic data are available from UK Biobank, for use in new medical research all around the world. Indeed, hundreds of research projects are already under way or have reported new findings on a wide range of illnesses including cancer, heart disease, diabetes, stroke, osteoporosis and schizophrenia.

A team of Oxford University researchers have worked on behalf of UK Biobank to apply sophisticated new statistical techniques to genetic information from all 500,000 volunteer UK Biobank participants. They have ensured high data quality and been able to impute the number of testable genetic variants -- the letters in our DNA code that vary from person to person -- from 800,000 to 96 million, a more than 100-fold increase in useful data. Imputation compares the selected genotyped DNA with analysis of the full human genome, to allow scientists to accurately predict DNA code at non-selected sections.

Today - Paper - Research - Triumph - Culmination

Today's paper celebrates this research triumph, which is a culmination of several years' work carried out by a consortium of genetics experts. This has included statistical teams led by Professor Jonathan Marchini and Professor Peter Donnelly at Oxford's Wellcome Centre for Human Genetics, and the laboratory expertise of Samantha Welsh and her team at the UK Biobank coordinating centre, and at Affymetrix which undertook the genotyping.

Professor Rory Collins, UK Biobank Principal Investigator, said that UK Biobank is enabling novel genetic health research worldwide. Almost 1,000 genetics-based research projects have so far been submitted to UK Biobank, with many more planned.

Thanks - Vision - UK - Biobank - Funders

"Thanks to the vision of UK Biobank's funders, the altruism of the study participants and the contributions of a large number of scientists who have helped us along the way, UK Biobank is coming of age as a force in health research," Professor Collins said.

Professor Marchini, who led the imputation work, said: "The UK Biobank dataset represents a step...
(Excerpt) Read more at: ScienceDaily
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