Trio win Nobel Chemistry Prize for evolution research

phys.org | 10/3/2018 | Staff
monna (Posted by) Level 3
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American scientists Frances Arnold and George Smith and British researcher Gregory Winter won the Nobel Chemistry Prize on Wednesday for harnessing the principles of evolution to develop proteins used to make everything from biofuels to pharmaceuticals, the jury said.

Arnold won one half of the nine million Swedish kronor (about $1.01 million or 870,000 euros) prize, while Smith and Winter shared the other half.

Royal - Swedish - Academy - Sciences - Researchers

The Royal Swedish Academy of Sciences says the three researchers who were awarded this year's Nobel Prize in chemistry "harnessed the power of evolution" to develop enzymes and antibodies that have led to new pharmaceuticals and biofuels.

Frances Arnold of the California Institute of Technology was awarded half the prize for conducting the first directed evolution of enzymes, leading to more environmentally friendly manufacturing of chemicals, including drugs, and in the production of renewable fuels.

George - Smith - University - Missouri - Gregory

George Smith of the University of Missouri and Gregory Winter of the MRC Laboratory of Molecular Biology in Cambridge, England, share the other half of the prize. Smith developed a new way to evolve proteins and Winter used the method for evolving antibodies with the aim of producing new drugs.

The first drug based on this work is used against rheumatoid arthritis, psoriasis and inflammatory bowel disease, the academy said.

Royal - Swedish - Academy - Sciences - Announcement

The Royal Swedish Academy of Sciences announcement:

"for the directed evolution of enzymes"

Phage - Display - Peptides - Antibodies

"for the phage display of peptides and antibodies"

The power of evolution is revealed through the diversity of life. The 2018 Nobel Laureates in Chemistry have taken control of evolution and used it for purposes that bring the greatest benefit to humankind. Enzymes produced through directed evolution are used to manufacture everything from biofuels to pharmaceuticals. Antibodies evolved using a method called phage display can combat autoimmune diseases and in some cases cure metastatic cancer. Since the first seeds of...
(Excerpt) Read more at: phys.org
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