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Now Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko have collaborated with colleagues to offer new insights on how gene activity drives the development of cartilage. Their findings appear Friday in Nature Communications.
Based on their studies, the scientists identified and characterized, for the first time, unique cell populations that form the superficial zone of human joint cartilage. The zone has the most critical role in cushioning the joint and is often partially or completely lost in arthritis.
Results - Atlas - Skeletal - Development - Strategy
"Our results not only offer a unique molecular atlas of human skeletal development, but also define a strategy for joint cartilage repair," said Evseenko, the study's corresponding author and an associate professor of orthopedic surgery, and stem cell biology and regenerative medicine at the Keck School of Medicine.
In a series of experiments, postdoctoral scholar-research associate Gabriel Ferguson and postdoctoral scholar-research associate Ben Van Handel and colleagues compared the gene activity of developing human cartilage cells with several other cell types.
Cartilage - Cells - Types - Cells - Precursors
First they compared the cartilage cells to four other types of developing human cells: the precursors to bone, muscle, tendon and ligament. As the cartilage matured, the genes specific to cartilage became increasingly active, while genes related to the other cell types became...
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