"This could be a good start to developing new promising treatments for Huntington's disease, treatments that could be administered even before signs of the illness appear," said Alexander Osmand, researcher in the Department of Biochemistry and Cellular and Molecular Biology at the University of Tennessee, Knoxville, and coauthor of the study.
The disease, which causes the progressive deterioration of both mental and physical abilities, is the result of a genetic mutation of the huntingtin gene. All humans possess this gene, and studies suggest that is necessary to healthy development. Its mutated form, however, causes the rapid decay of specific neurons, eventually resulting in death.
Effects - Huntington - Disease - Adult - Mice
Usually, the effects of Huntington's disease are not apparent until an adult reaches their 30s or 40s. By studying mice, however, researchers have discovered that an array of effects may be seen much earlier.
Although these early symptoms are less clearly defined than the later, more debilitating effects, they could serve as an indicator to health care providers that further screening may be needed.
Researchers - Litters - Mice - Huntingtin - Gene
Researchers subjected several litters of mice carrying the human huntingtin gene...
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