Single dose of the cannabis compound CBD reduces psychotic symptoms by normalising brain activity

Mail Online | 4/16/2005 | Alexandra Thompson Senior Health Reporter For Mailonline
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A single dose of a supplement derived from cannabis reduces psychotic symptoms, despite psychosis being linked to the long-term use of the Class B drug, new research suggests.

When suspected psychosis patients are given a single 600mg oral dose of the compound cannabidiol (CBD), their symptoms become less severe, a UK study found today. Such symptoms can include hallucinations, delusions, anxiety and insomnia.

CBD - Opposition - Component - THC - Psychosis

CBD appears to work in opposition to the other cannabis component THC, which worsens psychosis symptoms and is what makes users 'high'. CBD that is legally sold in the UK must contain very low levels of THC.

After taking CBD, MRI scans of suspected psychosis patients suggest the supplement helps to 'readjust brain activity to normal levels', according to the researchers.

Cannabis - Prescription - UK - Government - July

Medical cannabis is available on prescription in the UK after it was approved by the Government last July.

Marijuana is legal for medicinal purposes in 30 US states, including California, Florida and Ohio. Nine states permit the drug for recreational use.


How the research was carried out

The researchers, from King's College London, analysed 33 people in their early-to-mid 20s who were experiencing distressing psychotic symptoms but had not been diagnosed with psychosis.

Individuals - People - Age

These individuals were compared against 19 healthy people with an average age of 23.

A 600mg dose of CBD was given to 16 of the suspected psychosis patients, with the remaining 17 receiving a placebo.

Dose - Psychosis

This dose was chosen due to it previously being shown to be effective in psychosis.

Three hours later, all of the participants were studied...
(Excerpt) Read more at: Mail Online
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