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Scientists from the Okinawa Institute of Science and Technology Graduate University (OIST), have identified 85 genes essential for fission yeast cells at rest, under nutritionally limited environmental conditions, to maintain their ability to return to the dividing mode. The study sheds light on the genetic network required for resting cells like cancer stem cells to reactivate, and has potential applications in developing new therapies to treat cancer. The study has been published in the journal Science Advances.
In all living organisms, cells multiply when nutritional and environmental conditions are favorable for cell division. The availability of ample nutrition via a nitrogen source is one of the main deciding factors necessary to initiate the cell division process, as nitrogen is needed to make DNA, RNA and protein. When an external nitrogen source is absent, cells must recycle the intracellular nitrogen source and remain in a non-dividing (quiescent) state, alternatively known as the G0 phase. The medium contains an excess carbon energy source (glucose) so that the metabolism of G0 cells in brain or in muscle is fully active. In the G0 phase, the cells change into shapes different from the dividing mode, and they modify the way they work to cope with the scarcity of the nitrogen source, reactivating for division only when favorable amounts of nitrogen return. This ability of cells to restart the cell division process is referred to as mitotic competence (MC).
G0 - Cells - Ability - Conditions - Dr
"Understanding how G0 cells maintain their ability to revive themselves on experiencing favorable conditions is important," says Dr. Kenichi Sajiki, a researcher in the laboratory of Professor Mitsuhiro Yanagida, and the lead author of the paper. For this study, he and his colleagues examined a collection of 3280 fission yeast deletion mutant cell strains that had one of their genes partially or fully deleted.
Fission yeast cells were encouraged...
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