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A group of Japanese researchers has developed a technology to create a hybrid catalyst from simple-structured, commercially available rhodium and organic catalysts, which reduces chemical waste and produces molecules with high selectivity of an enantiomer, a pair of molecular structures that are non-superimposable mirror images of each other. This technology is expected to assist in rapid and low-cost drug synthesis.
The technology was developed by scientists including Professor Shigeki Matsunaga and Assistant Professor Tatsuhiko Yoshino, both of Hokkaido University's Faculty of Pharmaceutical Science, and Professor Kazuaki Ishihara and Associate Professor Manabu Hatano, both of Nagoya University's Graduate School of Engineering.
Structures - Enantiomer - Effectiveness - Drugs - Chemical
The two molecular structures found in an enantiomer have different effectiveness when used as drugs, even though their chemical properties are similar. One molecular structure can be effective, while the other can trigger serious side effects. It is therefore important to select the desired molecular structure for chemical conversion when synthesizing drugs. In addition to manufacture medicines with less waste, it is necessary to have the chemical conversion occur only at a desired carbon-hydrogen bond with the use of catalysts. To fulfill these two requirements, scientists have been using expensive rhodium catalysts made in complex, multi-phased production processes. The limited availability of such rhodium catalysts has made it...
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