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Reactive molecules derived from molecular oxygen, known as reactive oxygen species (ROS), increase dramatically in the body during times of environmental stress or disease. This stress can result in significant damage to cells and is associated with negative health consequences such as aging, male infertility, degenerative diseases and cancer.
"We think there's an ideal intermediate concentration, but neither extreme is good," said Daniel Suter, a professor of biological sciences at Purdue University.
Study - Suter - Team - Enzyme - ROS
In a recent study, Suter's team looked at an enzyme that produces ROS in zebrafish embryos to see if it's essential to the development of their nervous systems. Inhibiting this enzyme, NADPH oxidase (Nox), resulted in complications with signaling between the eyes and the brain. The findings were published in The Journal of Neuroscience.
The research team used a drug called celastrol to inhibit Nox activity, which led to defects in the formation of the ganglion cell layer and optic nerve, both of which send signals...
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