The researchers found that nicotine preloading reduces craving intensity and seems to make quitting easier, but that this beneficial effect may have been masked by a concurrent reduction in the use of varenicline in the period after quit day. As varenicline is the most effective smoking cessation drug, this may have undermined the benefit of preloading.
If it were possible to overcome this unintended consequence, nicotine preloading "could lead to a worthwhile increase in long term smoking abstinence," they say.
Drugs - Tobacco - Cessation - Treatment - Support
Although there have been several new drugs for tobacco cessation since the 1970s, treatment has remained largely the same, with behavioural support to motivate and strengthen a person's resolve to remain abstinent and drugs to reduce the strength of urges to smoke after quit day.
Some studies have suggested that using nicotine replacement therapy before a quit attempt is more effective than when used in the conventional way to support abstinence, while other studies suggest preloading has no effect.
Research - Team - UK - Centre - Tobacco
A research team from the UK Centre for Tobacco and Alcohol Studies, led by Professor Paul Aveyard at the University of Oxford, set out to examine the effectiveness of a nicotine patch worn for four weeks before a quit attempt.
Their trial involved 1,792 nicotine dependent adults from four cities across England, who smoked an average of 19 cigarettes a day. Most were middle aged and had lower levels of education than the UK average, half were male and a quarter were from minority ethnic groups.
Smokers - Groups - Cessation - Drug - Therapy
Smokers were randomly assigned to two groups -- half received standard smoking cessation drug therapy and behavioural support, while the other half received the same treatment plus a daily nicotine patch...
Wake Up To Breaking News!