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Research conducted in the University of Helsinki may help in developing specific inhibitors that would slow down actin-dependent movement of cancer cells.
Adenosine triphosphate (ATP) produced by mitochondria is the main energy source for chemical reactions in cells. A human typically produces up to his or her own body weight of ATP over the course of the day.
User - ATP - Cell - Types - Cytoskeleton
A major user of ATP in many cell types is the actin cytoskeleton, which is composed of dynamic protein filaments that provide the force for cells to move around and change their shape. For example in neurons and immune cells, approximately half of the ATP is estimated to be consumed in motile and morphogenetic processes driven by ATP-dependent growth of actin filaments. However, the mechanism by which ATP is loaded to actin has remained a mystery.
Researchers at Institute of Biotechnology, University of Helsinki have now discovered that the abundant and evolutionarily conserved protein,cyclase-associated protein, is responsible...
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