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They first starred together in the 1992 film Bram Stoker's Dracula, before appearing together again in 2006's A Scanner Darkly and then The Private Lives Of Pippa Lee in 2009.
And Keanu Reeves, 53, and Winona Ryder, 46, are teaming up again, this time for the romantic comedy Destination Wedding.
Trailer - Film - Wednesday
A trailer was released for the film on Wednesday.
Scroll down to see video
Pair - Star - Frank - Lindsay - Strangers
The pair star as Frank and Lindsay, two prickly strangers who realize after clashing at an airport that they're both headed for the same wedding.
'So we're just the people you don't know where to stick?' laments Ryder's character Lindsay, as the couple can be seen seated away from the other guests at the wedding.
Frank - Reeves
'Might as well just stick us together,' observes Frank, played by Reeves.
'I don't want to be a person you don't know where to stick,'...
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