WNT signaling pathways play important roles in cell growth, development and cancer. The classical or "canonical" WNT pathway and its atypical, "non-canonical" counterpart share a protein called DVL2 that "transduces" or converts one kind of signal to another.
Now Jason MacGurn, Ph.D., and colleagues have shown that two other proteins, USP9X and WWP1, act on DVL2 to regulate both WNT signaling pathways.
Whereas - WWP1 - DVL2 - Protein - Ubiquitin
Whereas WWP1 suppresses DVL2 by tagging it with a protein called ubiquitin that...