LongRoom News › SciTech
Using fragment-based approaches to discover new antibiotics
phys.org
| 6/21/2018
| Staff
Click For Photo: https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/hires/2018/usingfragmen.jpg
In the July 2018 issue of SLAS Discovery, a review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics.
Authors Bas Lamoree and Roderick E. Hubbard of the University of York (UK) explain how FBLD works and illustrate its advantages over conventional high-throughput screening (HTS). Specifically, how FBLD increases the chances of finding hit compounds; how its methods can deliver hits without the massive investment required for HTS; and how by starting small, FBLD gives medicinal chemists more opportunities to build more drug-like compounds. These principles are illustrated in the review and supported with recent examples of discovery projects against a range of potential...
In the July 2018 issue of SLAS Discovery, a review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics.
Authors Bas Lamoree and Roderick E. Hubbard of the University of York (UK) explain how FBLD works and illustrate its advantages over conventional high-throughput screening (HTS). Specifically, how FBLD increases the chances of finding hit compounds; how its methods can deliver hits without the massive investment required for HTS; and how by starting small, FBLD gives medicinal chemists more opportunities to build more drug-like compounds. These principles are illustrated in the review and supported with recent examples of discovery projects against a range of potential...
(Excerpt) Read more at: phys.org
Wake Up To Breaking News!
Tagged:
From my diary It’s been an interesting couple of days. I was working on the Passio of St Valentine, and I really felt that I...
‘Run the Race’ stars share the impact Tim Tebow's film has made on their lives Tanner Stine and Evan Hofer, the stars of the...
Proactive Plan For Leadership Development In the Church One of the most challenging situations in my counseling ministry is...
Wow: A Journalist Tells Bishops to Clean Up Their Act or ‘We Journalists Will Be Your Worst Enemies’ The Catholic Herald dubbed...
FEEDING YOUR TEMPLE: BODY, MIND, AND SPIRIT In college, I was quite the busy-body. I found my self-worth in participating in...
Cardinal Marx: Transparency is decisive in the credibility of the Church Vatican City, Feb 23, 2019 / 11:29 am (CNA).- Cardinal...
Amazon Air cargo plane operated by Atlas crashes in Texas, killing 3 on board An Atlas cargo plane flying on behalf of...
X-rays Might be a Better Way to Communicate in Space In the coming years, thousands of satellites, several next-generation...
Thousands of yellow vest protesters take to the streets across France for a 15th weekend running
Read the Full Article
Read the Full Article
The smell of food controls cellular recycling and affects life expectancy The smell of food induces a variety of physiological...
Complete world map of tree diversity Biodiversity is one of Earth's most precious resources. However, for most places in the...
Get a lifetime of language learning with Mondly for $69.99 Many of us will fly abroad at some point this year. To experience...
Nicole Holofcener: ‘Can You Ever Forgive Me?’ Director Was Cheated Out of an Oscar Nomination “Can You Ever Forgive Me?”...
Glenn Close's Dog Was the Real Winner at the Independent Spirit Awards Who needs a human date to an awards show when you can...
Independent Spirit Awards 2019: Chloe Grace Moretz puts her chest on display Chloe Grace Moretz put her chest on display on...
Indie Spirits: Even Without a Best Director Win, This Year’s Show Was Still About Female Creative Power The tone of this year’s...
The Five Best Submarine Movies of All-Time The thought of being at sea is, for some people, unbearable as there...
Independent Spirit Awards 2019 Brings Laughs and Parodies Fyre Festival Doc: Best Moments Anything goes at the 2019 Independent...
Raccoons Keep Calm and Carry On! These cute raccoons appear to be waiting to be fed with the front one looking to keep every...
Rare "Dumbo" Octopus! This octopus fans out its tentacles as if showing off while having its picture taken!
Subway in 1905 - New York City, NY! This short glimpse into the past reveals a time radically different from today.
This Turkey Gives Out Hugs! This turkey has a great strategy for avoiding being a Thanksgiving dinner - just give another way,...
Tornado Coming in Laramie! This classic stovepipe in Laramie is causing some havoc as it continues on its way looking very...
Short, But Torrential Downpour in Nevada! This microburst drops lots of water on the Nevada landscape!
Breaking News
Job Creators Network Fires Back at Alexandria Ocasio-Cortez with Two More Times Square Billboards AWKWARD: Bernie Sanders would explain why socialism failed in Venezuela, but it’s complicated so let’s change the subject The identity-politics police come for Bernie Sanders Green New Deal Activists Use Kids to Confront Sen. Dianne Feinstein, and The Internet Goes Wild Thousands of yellow vest protesters take to the streets across France for a 15th weekend running
Read the Full Article
Read the Full Article
Categories